Each lymphoma is placed under the normal cell it most resembles. The tumor keeps the immunophenotype, the genetic scars, and often the behavior of the stage where differentiation was arrested.
The horizontal path is the life of a lymphocyte: bone marrow or thymus on the left, lymph node in the middle, periphery and terminal differentiation on the right. Text along the path names the DNA-modifying process active there; translocations arise where those processes are active.
Click a drawn cell for the normal stage. Click a lymphoma for its profile. The grid at the bottom shows how the diagnostic markers switch on and off across development; click a marker name to load it into the matcher. Both lineages can be shown together (Both), which drops the marker grid to fit. The Presentations tab works the other way round: start from a clinical syndrome such as HLH or hypercalcemia and see which lymphomas cause it.
Indolent: years, often observed, rarely cured
Aggressive: months, treated with intent to cure or control
Highly aggressive: weeks, intensive therapy, emergencies at presentation
Marker positive at that stage
Partial, dim, or a subset
Negative
Phenotypes are simplified typical patterns. Treatment is summarized at a high level and changes quickly; check current guidelines before applying.